Supported Studies

We work closely with our partners to fund lab research of rare and underfunded pediatric cancers. We also support clinical research in local hospitals through the work of the Children's Oncology Group.

Research studies that we have funded in 2016:

Children's Oncology Group - EveryChild Initiative
USA
Funding Partner: Jeff Gordon Children's Foundation

Research Institute at Nationwide Children's Hospital
Columbus, OH
Kevin Cassady & Christopher Walker
Improving Immune-Mediated Oncolytic Viral Therapy: Engineering Tumor Vaccine Elements into the Virus
Funding Partner: Alex's Lemonade Stand

Research Institute at Nationwide Children's Hospital
Columbus, OH
Researcher: Kathleen Pishas
Pre-clinical Evaluation of LSD1 Inhibitors for the Treatment of Pediatric Ewing's Sarcoma
Funding Partner: Alex's Lemonade Stand

Brigham's and Women's Hospital
Boston, MA
Cichowski, Karen
Merestinib (MNKi) + MEKi for the treatment of MPNST
Funding Partner: Children's Tumor Foundation

Brigham's and Women's Hospital
Boston, MA
Cichowski, Karen
Romidepsin (HDACi) + mTORi for the treatment of MPNST
Funding Partner: Children's Tumor Foundation

California Institute of Technology
Pasadena, CA
John E. Robinson
Utilizing CLARITY, optogenetics, and novel viral vectors to deconstruct and reverse ADHD-like phenotypes associated with neurofibromatosis type 1
Funding Partner: Children's Tumor Foundation

University of Texas Southwestern Medical Center
Dallas, TX
Jean-Philippe Brosseau
Fibroblasts: The missing gap in Neurofibromatosis
Funding Partner: Children's Tumor Foundation

Geisel School of Medicine at Dartmouth College
Hanover, NH
Stephanie J. Bouley
Targeting tumors with NF1 loss via modulation of autophagy
Funding Partner: Children's Tumor Foundation

Brigham and Women's Hospital
Boston, MA
Thomas DeRaedt (K.Cichowski lab)
Developing an advanced in vivo modeling system to test drivers and explore therapies for NF1 associated central nervous system tumors
Funding Partner: Children's Tumor Foundation

Johns Hopkins University
Baltimore, MD
Verena Staedtke
Evaluation of Mebendazole as Chemoprevention in a Neurofibromatosis 1 Transgenic Mouse Model
Funding Partner: Children's Tumor Foundation

University of Pennsylvania
Philadelphia, PA
Jeffrey Field
MPNST profiling and screening: extension for exome sequencing of the cell lines screened
Funding Partner: Children's Tumor Foundation

Columbia University
New York, NY
Antonio Iavarone
Identification, functional characterization and therapeutic exploitation of the integrated landscape of genetic and epigenetic alterations in glioma from patients with NF1
Funding Partner: Children's Tumor Foundation

The Washington University, Children's Hospital of Philadelphia, UCSF, DKFZ (Germany)
International Consortium
David Gutmann, Michael Fisher, Bill Weiss, Stefan Pfister, David Jones, Joanna Phillips, Adam Resnik, Angela Waanders
Identification, functional characterization and therapeutic exploitation of the integrated landscape of genetic and epigenetic alterations in glioma from patients with NF1
Investigators
Funding Partner: Children's Tumor Foundation

Medical University of South Carolina
Charleston, SC
Steven Lewis Carroll
Combinatorial Therapy with Receptor Tyrosine Kinase Inhibitors for Malignant Peripheral Nerve Sheath Tumors
Funding Partner: Children's Tumor Foundation

Cincinnati Children's Hospital Medical Center
Cincinnati, OH
Nancy Ratner
Mechanisms of Resistance to MEK Inhibition in Neurofibroma
Funding Partner: Children's Tumor Foundation

Massachusetts General Hospital
Boston, MA
Andrea McClatchey
Expanded testing of centrosome-unclustering drugs in NF2-mutant tumors
Funding Partner: Children's Tumor Foundation

University of Chicago
Chicago, IL
Mark Applebaum
Identification of Hypoxia Induced Pathways Driving Aggressive Neuroblastoma
Funding Partner: Bear Necessities Pediatric Cancer Foundation

Dana Farber Cancer Institute
Boston, MA
Mark Kieran
DIPG research and clinical trials
Funding Partner: Prayers From Maria

Cleveland Clinic Children's Hospital
Cleveland, OH
Rabi Hanna
Quantification of therapeutic responses in pediatric and adolescents and young adults (AYA) Lymphoma patients via detection of circulating tumor DNA
Funding Partner: Cleveland Clinic Children's Hospital

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