Supported Studies

We work closely with our partners to fund lab research of rare and underfunded pediatric cancers. We also support clinical research in local hospitals through the work of the Children's Oncology Group.

Research studies that we have funded in 2017:

Cleveland Clinic Children‘s Hospital
Cleveland, OH
Neetu Gupta & Peter Anderson
Targeting the function of Ezrin in Rhabdomyosarcoma
Funding Partner: Alex‘s Lemonade Stand Foundation

Nationwide Children‘s Hospital
Columbus, OH
Susann Brady-Kalnay & Efstathios Karathanasis
Targeting pediatric brain tumors using PTPmy Nanachains with Radiofrequency-Releasable Therapeutics
Funding Partner: Alex‘s Lemonade Stand Foundation

Research Institute at Nationwide Children's Hospital
Columbus, OH
Researcher: Kathleen Pishas
Pre-clinical Evaluation of LSD1 Inhibitors for the Treatment of Pediatric Ewing's Sarcoma
Funding Partner: Alex's Lemonade Stand

The Children‘s Hospital of Philadelphia
Philadelphia, PA
Jo Lynne Harenza
Merestinib (MNKi) + MEKi for the treatment of MPNST
Defining the subclonal landscape of high-risk neuroblastoma
Funding Partner: Bear Necessities Pediatric Cancer Foundation

Dana Farber Cancer Institute
Boston, MA
Kimberly Stegmier
New metabolic targets in Acute Lymphoblastic Leukemia (ALL)
Funding Partner: Bear Necessities Pediatric Cancer Foundation

The Children‘s Oncology Group
Nationwide
Peter Adamson, COG Chair
Project Everychild
Funding Partner: Bear Necessities Pediatric Cancer Foundation

Cleveland Clinic Children‘s Hospital
Cleveland, OH
Stacey Zahler
Defining Markers of Radiosensitivity: Radiogenomic Profiiling of Rhabdomyosarcoma
Funding Partner: Cleveland Clinic

Brighham & Women‘s Hospital in partnership with University of California SF
Boston, MA
Kevin Shannon
Preclinical Screening in Myeloid Malignancies Initiated by NF1 Inactivation
Funding Partner: Children‘s Tumor Foundation

University of Padua
Italy
Monica Masgras
TRAPping the metabolic adaptations of NF1-associated tumors
Funding Partner: Children‘s Tumor Foundation

California Institute of Technology
Pasadena, CA
John Robinson
Utilizing CLARITY, optogenetics, and novel viral vectors to deconstruct and reverse ADHD-like phenotypes associated with neurofibromatosis type 1
Funding Partner: Children‘s Tumor Foundation

University of Texas Southwestern Medical Center
Dallas, TX
Jean-Philippe Brosseau
Fibroblasts: The missing gap in Neurofibromatosis
Funding Partner: Children‘s Tumor Foundation

Columbia University
New York, NY
Antonio Iavarone
Identification, functional characterization and therapeutic exploitation of the integrated landscape of genetic and epigenetic alterations in glioma from patients with NF1
Funding Partner: Children's Tumor Foundation

Geisel School of Medicine at Dartmouth College
Hanover, NH
Stephanie J. Bouley
Targeting tumors with NF1 loss via modulation of autophagy
Funding Partner: Children‘s Tumor Foundation

Brigham and Women‘s Hospital
Boston, MA
Thomas DeRaedt & Karen Chicowski
Developing an advanced in vivo modeling system to test drivers and explore therapies for NF1 associated central nervous system tumors
Funding Partner: Children‘s Tumor Foundation

Johns Hopkins University
Baltimore, MD
Verena Staedtke
Evaluation of Mebendazole as Chemoprevention in a Neurofibromatosis 1 Transgenic Mouse Model
Funding Partner: Children‘s Tumor Foundation

University of Padova
Italy
Andrea Rasola
Targeting the mitochondrial chaperone TRAP1 to inhibit plexiform neurofibroma growth
Funding Partner: Children‘s Tumor Foundation

Columbia University
New York, NY
Antonio Iavarone
Identification, functional characterization and therapeutic exploitation of the integrated landscape of genetic and epigenetic alterations in glioma from patients with NF1
Funding Partner: Children‘s Tumor Foundation

Multi-Institutions
The Washington University, Children‘s Hospital of Philadelphia, University of California San Francisco, German Cancer Research Center (DKFZ)
David Gutmann, Michael Fisher, Bill Weiss, Stefan Pfister, David Jones, Joanna Phillips, Adam Resnick, Angela Waanders
Identification, functional characterization and therapeutic exploitation of the integrated landscape of genetic and epigenetic alterations in glioma from patients with NF1
Funding Partner: Children‘s Tumor Foundation

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